[关键词]
[摘要]
肺癌发病率和死亡率居全球恶性肿瘤首位,作为治疗主导方向的化疗,药物推陈出新,方案不断优化,疗效却已达“平台期”,究其原因,肺癌细胞的多药耐药(MDR)不容忽视。寻找肺癌化疗耐药逆转剂,逆转MDR 是肿瘤领域的研究热点。中药活性广泛而显著,高效小毒,多靶点逆转MDR,临床药效逐步得到肯定,但明确的逆转机制尚待研究。
[Key word]
[Abstract]
The incidence and mortality of lung cancer are in the first place of all cancers in the world. As the leading treatment, chemotherapy drugs continue to be updated, and the treatment plan is optimized, but the curative effect has reached the “platform stage”. To investigate the reason, the multi drug resistance (MDR) of lung cancer cells can not be ignored. MDR has become a hot research topic in the field of lung cancer for discovery of drug resistance reversal agents. Chinese materia medica (CMM) is active in a wide range, with high efficiency, low toxicity, and multiple targets, and can reverse MDR. The clinical efficacy of CMM is gradually confirmed, and its reversal mechanism is still to be studied.
[中图分类号]
[基金项目]
天津市应用基础及前沿技术研究计划(青年基金项目)(12JCQNJC07500);天津市高等学校科技发展基金计划项目(20110223)