[关键词]
[摘要]
南岭荛花Wikstroemia indica 为瑞香科荛花属植物,其根及根皮为常用中草药了哥王。近年来化学研究显示其根及根皮中含有大量的黄酮类成分以及木脂素、香豆素、甾醇等化合物;药理研究发现了哥王有显著的抗肿瘤作用,因此成为新药研发的热点。对文献中有关南岭荛花的化学成分和抗肿瘤药理活性研究进展进行综述,为进一步深入研究提供参考。
[Key word]
[Abstract]
Wikstroemia indica, belonging to family Thymelaeaceae and genus Wikstroemia Endl., was widely distributed in southern China, and its root and root bark were common traditional Chinese herbal medicine. So far large quantity of flavonoids had been isolated from the plant, together with other types of active principles, such as lignans, coumarins, sterols, and others. In recent years, the plant had the significant antitumor effect. Therfore, it becomes the hotspot of research and development. This paper reviews on the chemical constituents and antitumor activities of Wikstroemia indica in the literature, and provides a reference for the further research.
[中图分类号]
[基金项目]
国家自然基金青年项目(81303267,81302744);中国博士后基金资助项目(2014M550149,2015T80226)