目的 评价孟鲁司特钠在呼吸道合胞病毒(RSV)感染的儿童毛细支气管炎治疗中的应用价值。方法 120 例确诊RSV 感染性毛细支气管炎的患儿随机分为2 组,对照组和治疗组各60 例。对照组采用常规疗法,治疗组在对照组基础上加用孟鲁司特钠5 mg/次、口服1 次/d,比较治疗7 d 后两组的疗效及预后。结果 治疗组患儿的咳嗽消失时间、喘憋消失时间、呼吸困难消失时间、肺部湿罗音消失时间、住院时间均显著的低于对照组(P< 0.01)。治疗第3、7 天两组患儿的尿白三烯E4(LTE4)、血清半胱氨酸白三烯(CysLTS)、血氧饱和度(TcSaO2)均较治疗前显著好转(P< 0.05),且治疗组优于对照组(P< 0.05)。治疗第7 天治疗组患儿的临床有效率为95%,显著高于对照组的83.33%(P< 0.05);治疗组的复发率为3.33%,显著低于对照组的13.33%(P< 0.05)。结论 孟鲁司特钠结合常规疗法治疗RSV 毛细支气管炎具有缩短治疗时间、尽快缓解临床症状,改善LTE4、CysLTS 炎症因子的作用,从而有效提高临床疗效。

Objective To evaluate the application value of montelukast sodium in the treatment of bronchiolitis infection induced by respiratory syncytial virus (RSV). Methods The confirmed RSV infection bronchiolitis children (120 cases) were randomly divided into control (n = 60) and treatment (n = 60) groups. The patients in the control group were given conventional therapy, while the patients in the treatment group were administered with montelukast sodium, po 5 mg/time, 1 time/d, after 5 d the treatment effects of two groups were compared. Results The disappeared time of cough, wheezing disappearance time, breathing difficulties disappearance time and lung wet rales disappearance time, hospitalization time in treatment group were significantly lower than those of normal group (P<0.01) in children. LTE4, serum CysLTS, and TcSaO2 were significantly improved in days 3 and 7 in two groups after treatment, compared with those before treatment (P<0.05), and the treatment group was significantly better than the conventional group (P<0.05). The clinical effective rate of treatment group was 95%, significantly higher than that of the conventional group (83.33%, P<0.05), and the recurrence rate was 3.33% in the treatment group was significantly lower than that in the conventional group (13.33%, P<0.05). Conclusion Montelukast sodium combined with conventional therapy in the treatment of RSV bronchiolitis has shorter treatment time, relieves the clinical symptoms as soon as possible, and improves LTE4, CysLTS role of cytokines, which can effectively improve the clinical efficacy.