目的 探讨瑞替普酶辅助治疗脑缺血所致头晕的效果。方法 2012年9月-2014年2月选择河北省秦皇岛市北戴河医院收治的脑缺血所致头晕患者120例,根据随机抽签原则分为治疗组与对照组各60例,对照组给予常规治疗,治疗组在此基础上加用瑞替普酶治疗,均治疗4周。结果 治疗后治疗组与对照组的有效率分别95.0%和83.3%,治疗组明显高于对照组(P<0.05)。两组治疗后的基底动脉与椎动脉血流速度都明显增加(P<0.05),同时治疗后治疗组的基底动脉与椎动脉血流速度明显高于对照组(P<0.05)。两组治疗后的ABCD2评分均明显下降(P<0.05),与对照组相比,治疗后治疗组的ABCD2评分明显较低(P<0.05)。结论 脑缺血所致头晕在临床上比较常见,瑞替普酶的辅助治疗能有效降低ABCD2评分,改善血流状况,从而提高治疗疗效。

Objective To investigate the effects and related mechanisms of different medications for treating dizziness induced by cerebral ischemia. Methods From September 2012 to February 2014, selected 120 patients with dizziness induced by cerebral ischemia were equally divided into treatment group and control group based on the principle of a random draw, the patients in control group received conventional therapy, on the basis of the patients in treatment group were treated with reteplase treatment. Results After treatment, the efficiencies in the treatment group and the control group were 95.0% and 83.3% with statistically significant difference between two groups (P < 0.05). The blood flow velocities of basilar artery and vertebral artery in two groups after treatment were significantly increased (P < 0.05), while the blood flow velocities of basilar artery and vertebral artery in the treatment group were significantly higher (P < 0.05). After treatment, the ABCD2 scores were significantly decreased (P < 0.05), but ABCD2 score in treatment group was significantly lower than that in the control group (P < 0.05). Conclusion Cerebral ischemia-induced dizziness is more common in clinical practice, and reteplase adjuvant therapy can effectively reduce ABCD2 score, improve blood flow, thereby improve therapeutic efficacy.

秦皇岛市科技支撑计划项目(201302A185)