目的 探讨利巴韦林和喜炎平联合治疗小儿轻度手足口病的效果。方法 小儿轻度手足口病150例根据随机抽签原则分为治疗组与对照组各75例,两组都给予基础治疗,然后对照组给予利巴韦林治疗,治疗组给予利巴韦林和喜炎平联合治疗,都治疗7 d。结果 治疗后治疗组的有效率为98.7%,对照组为89.3%,与对照组相比,治疗组明显较高(P<0.05)。与对照组相比,治疗组的退热时间、皮疹消退时间、咳嗽痊愈时间及住院时间明显缩短(P<0.05)。治疗组的血清EV71或CA16抗体转阴率明显高于对照组,转阴时间明显低于对照组(P<0.05)。两组患儿均无不良反应发生。结论 利巴韦林和喜炎平联合治疗小儿轻度手足口病能明显改善临床症状,缩短血清EV71与CA16抗体转阴时间,从而提高治疗疗效。

Objective To explore the effects of ribavirin combined with Xiyanping in treatment of mild children hand, foot and mouth disease (HFMD). Methods Children (150 cases) with mild HFMD were randomly divided into treatment group and control group (n = 75), both groups were given basic treatment and the control group were given ribavirin treatment, the treatment group were given ribavirin combined with Xiyanping for 7 d. Results After treatment, the total efficiencies in the treatment group and control group were 98.7% and 89.3%, respectively, and the total efficiency were significantly higher in the treatment group (P < 0.05). The cooling time, rash subsided time, recovery time, and hospital stay in the treatment group were significantly less than those in the control group (P < 0.05). The female ratio of serum EV71, CA16 and the clearance time in the treatment group were significantly lower than control group (P <0.05). There were no adverse reactions in two groups. Conclusion Ribavirin combined with Xiyanping can significantly improve the clinical symptoms and shorten the serum EV71 and CA16 antibody clearance time, thereby enhance the therapeutic efficacy.