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[摘要]
目的 探讨复方苦参注射液治疗Ⅲ~Ⅳ期癌症患者癌性疼痛的临床效果。方法 2010年1月至2014年1月山东省胸科医院肿瘤内科收治的122例恶性肿瘤患者, 随机分为治疗组和对照组, 每组61例。对照组采用常规治疗, 治疗组在常规治疗的基础上加用复方苦参注射液25 mL溶于250 mL生理盐水中静滴, 1次/d, 两周为1个疗程。对两组患者治疗后的疼痛评分、疼痛缓解的有效率及不良反应情况进行评价。结果 治疗后治疗组患者疼痛评分降低显著, 两组间差异具有统计学意义(P<0.05);治疗组和对照组患者疼痛缓解的有效率分别为81.97%和52.45%, 差异具有统计学意义(P<0.05)。结论 复方苦参注射液可有效缓解Ⅲ~Ⅳ期癌症患者癌性疼痛, 无明显不良反应, 值得深入研究。
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[Abstract]
Objective To study the clinical analysis of therapeutic effects of Compound Sophorae Injection on the cancer pain of Ⅲ-Ⅳ stage cancer patients. Methods The clinical information of 122 cases of metastatic bone cancer patients suffered with pains was collected retrospectively from January 2010 to January 2014, these patients were selected and randomly divided into observation group (based on the conventional treatment, Compound Sophorae Injection 25 mL was added into 250 mL normal saline solution for iv drip once daily) and the control group (conventional treatment), and there were 61 patients in each group. The pain score, effective rate of pain relief, and adverse reactions were compared after treatment between the two groups. Results After the treatment, the pain scores of the patients in the two groups decreased, and the pain score of the patients in the observation group was significantly lower than that of the patients in the control group (P<0.05). The effective rates of pain relief of the patients in the observation group and the control group were respectively 81.97% and 52.45% (P<0.05). The incidence of adverse reactions was lower in the observation group than that in the control group (P<0.05). Conclusion Compound Sophorae Injection could effectively relieve the cancer pain of Ⅲ-Ⅳ stage cancer patients, and it is worth the further research in clinic.
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