[关键词]
[摘要]
目的 探讨瑞舒伐他汀致不良反应的一般情况和特点,为临床合理用药提供参考。方法 以“瑞舒伐他汀”为主要检索词,对2000年1月—2014年9月中国期刊全文数据库进行检索,收集瑞舒伐他汀致不良反应的12例病例报道,探讨其特点,并提出合理用药建议。结果 8例患者为男性,4例女性,平均年龄(70.08±1.78)岁,瑞舒伐他汀的剂量为5~10 mg/d,不良反应一般在使用瑞舒伐他汀5 d后发生,主要表现为肝损害和横纹肌溶解。停药并进行相应治疗1周后不良反应明显好转,出现死亡病例1例。结论 严格按照药品说明书用药、加强用药监测、对发生的不良反应及时处理是防控瑞舒伐他汀致不良反应有效措施。
[Key word]
[Abstract]
Objective To investigate the general rules and characteristics of adverse effects induced by Rosuvastatin and, to provide the reference for clinical rational use of drug. Methods “Rosuvastatin” as the main key words to search in Chinese periodical full text database in January 2000—September 2014. Report on 12 cases with Rosuvastatin-induced adverse reactions were collected, the characteristics were discussed, and some reasonable recommendations were put forward. Results Eight patients were male and 4 were female, mean age was (70.08±1.78), Rosuvastatin dose was 5-10 mg/d, the adverse reactions generally occurred in the use of Rosuvastatin 5 d, mainly for liver damage and rhabdomyolysis. While the adverse reaction was improved by withdrawing drug then by corresponding treatment for 1 week. One death case appeared. Conclusion In strict accordance with the use of drug instruction, strengthening the drug monitoring, the treatment of reaction in time is the effective measures for the prevention and control of Rosuvastatin adverse reactions.
[中图分类号]
[基金项目]