[关键词]
[摘要]
吡嗪酰胺是一线抗结核药,在肺结核的短程化疗中起重要作用。但在临床应用过程中发现该药有不良反应,可导致肝脏毒性,若不及时进行保肝治疗可导致患者死亡。目前对吡嗪酰胺肝脏毒性的作用机制尚不完全明确,因此对其所致肝脏损害的机制进行深入研究,以减少其不良反应则尤为重要。本文对国内外关于吡嗪酰胺肝脏毒性的临床报道、实验动物肝脏毒性表现、肝脏毒性的机制研究和研究中存在的主要问题等进行综述。
[Key word]
[Abstract]
Pyrazinamide is an important first-line drug used to treat tuberculosis that shortens the duration of tuberculosis therapy. However, hepatotoxicity has been reported during the investigation of pyrazinamide in clinical trials. Hepatotoxicity can lead fatal trouble if it is not recognized and prevented in time. However, the cellular effects of pyrazinamide and its mechanism of hepatotoxicity remain poorly understood. It is important to study the mechanism of pyrazinamide-induced hepatotoxicity and to reduce its adverse reaction. In this paper, the clinical reports about pyrazinamide-induced hepatotoxicity, experimental animal liver toxicity, study on the liver toxicity mechanism and the main problems existing in the research at home and abroad are reviewed.
[中图分类号]
[基金项目]
国家自然科学基金(81273604);山东省科学院青年科学基金项目(2013QN001)