相对于药物安全性评价的临床研究,实验动物的临床检验指标存在一定的特殊性,应结合受试药物、动物表现、其他实验结果及其他检测结果进行综合分析。结合相关理论及笔者的实践经验对这个问题进行简要分析与讨论,主要内容包括建立实验室的正常参考值、如何排除非受试物因素对检验结果的影响、对结果的统计分析等综合分析的前提、综合分析的总体思路与方法、如何对血液学指标、血液生化学指标及凝血指标进行具体分析。

There is a certain particularity in animal examinations comparing with clinical examinations. We should analyse comprehensively combining article, symptoms and signs of animal, the result of other test and determination. In this paper, we discuss this issue by combining the theory and our experience in clinical pathology. The main content is to establish the animal's normal reference values, how to exclude the effect of other factor on the clinical examination. On the statistic analysis of result, specific analysis idea and method of hematology, blood biochemistry, and blood clotting are reviewed.