目的 考察熊胆痔灵栓治疗内痔与混合痔的临床疗效。方法 将2009 年8 月—11 月5 个临床研究中心收治的内痔与混合痔患者216 人，随机分为2 组。治疗组162 例，使用熊胆痔灵栓直肠给药治疗；对照组54 例，使用麝香痔疮栓治疗，于治疗7 d 后对两组患者的中医证候疗效和临床疗效进行比较。结果 治疗组中医症候总有效率及各项症状消失率明显优于对照组，两组疗效比较统计学差异显著（P<0.01）。结论 熊胆痔灵栓治疗内痔与混合痔有效，不良反应小，值得临床进一步推广使用。

Objective To investigate the clinical effect of Xiongdan Zhiling Suppository for the treatment of internal hemorrhoids and mixed hemorrhoid. Methods The 216 patients with internal hemorrhoids and mixed hemorrhoid in five treatment centers from August to November, 2009, were randomly divided into two groups, 162 examples were in the the treatment group, which were rectally given Xiongdan Zhiling Suppository treatment: The 54 cases in the control group, which were given Shexiang Zhichuang Shuan treatment, in 7 d after the treatment the clinical curative effects on the patients between the two groups were compared. Results the total effective rate and symptom disappeared rate in the treatment group were better than those in the control group, there was a significant statistical difference between the two groups (P<0.01). Conclusion Xiongdan Zhiling Suppository is useful for the treatment of internal hemorrhoids and mixed hemorrhoid and worthy of further clinical use.