[关键词]
[摘要]
目的 了解甲硝唑致出血性膀胱炎的一般情况和特点,为临床合理用药提供参考。方法 以“甲硝唑”并含“出血性膀胱炎”为主要检索词,对1990 年—2013 年中国期刊全文数据库、维普及万方数据库文献进行检索,收集甲硝唑致出血性膀胱炎的10 例病例报道,探讨不良反应发生的特点,并提出合理用药建议。结果 5 例患者为女性,5 例男性,平均年龄(37.70±5.10)岁,在使用甲硝唑2~3 d 后发生出血性膀胱炎,甲硝唑的剂量为0.6~1.4 g/d,停药3~7 d 后出血性膀胱炎明显好转,没有死亡病例。结论 严格按照药品说明书用药、加强用药监测、对发生的反应及时处理是防控甲硝唑致出血性膀胱炎有效措施。
[Key word]
[Abstract]
Objective To clarify the general situation and characteristics of Metronidazole-induced hemorrhagic cystitis so as, to provide the reference for clinical rational drug use. Methods "Metronidazole" and contain "hemorrhagic cystitis" as the main search term, for 1990-2013 China Academic Journal, VIP and WanFangDATA literature retrieval, the Metronidazole-induced hemorrhagic cystitis 10 cases reports were collected, its features of side effect were explored and the suggestion for rational use of drugs was put forward. Results Five patients were female and five male, their mean age was (37.70 ± 5.10), hemorrhagic cystitis occurred in the use of Metronidazole 1-3 d, metronidazole dose was 0.6-1.4 g/d, hemorrhagic cystitis was significantly improved after 3-7 d, withdrawal, there was no death. Conclusion In strict accordance with the package insert medication, the monitoring of medication should be strengthened. The effective measures is to timely treat the advers drug reaction occurried, in order to prevent the Metronidazole-induced hemorrhagic cystitis.
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