目的 观察壮骨1 号方的镇痛抗炎作用，为临床研究提供科学依据。方法 采用小鼠热板、醋酸扭体两种镇痛实验方法，观察壮骨1 号方的镇痛作用；采用小鼠二甲苯耳肿模型和大鼠棉球肉芽肿模型，观察壮骨1 号方的抗炎作用。结果 壮骨1 号方能有效地缓解由外界热刺激和化学性刺激引起的机体的疼痛，具有较好的镇痛作用，尤以高、中剂量效果显著；能有效的降低小鼠、大鼠的急性炎症和慢性炎症的发生，具有较好的抗炎效果。结论 壮骨1 号方具有显著的镇痛和抗炎效果。

Objective To observe the main pharmacodynamics of Zhuanggu No.1 Prescription. Methods Using the methods of mice hot plate and mice acetic acid-induced writhing, the analgesic effect of Zhuanggu No.1 Prescription was observed; Using the methods of xylene-induced ear inflammation in mice and granuloma swelling induced by cotton ball in rats, the effects of anti-inflammation was observed. Results Zhuanggu No.1 Prescription had good analgesic effect, and could relieve the pain induced by thermostimulation and chemical stimulation, especially at high and middle doses. In anti-inflammatory tests, Zhuanggu No.1 Prescription had good anti-inflammatory effect, and could reduce the acute and chronic inflammation in mice. Conclusion Zhuanggu No.1 Prescription has significant analgesic and anti-Inflammatory effects.

国家“重大新药创制”科技重大专项（2011ZX09201-201-21）