目的 考察不同塑料外包装材料对复方西瓜霜滴眼液中主要成分含量的影响。方法 采用常温留样和加速试验法（40 ℃±2 ℃），用高效液相色谱法（测定瓜氨酸含量）和气相色谱法（测定天然冰片、乙醇的含量），分别考察复方西瓜霜滴眼液在低密度聚乙烯（LDPE）、聚丙烯（PP）和聚酯（PET）3种塑料外包装材料中存放0、1、2、3、6个月后瓜氨酸、天然冰片和乙醇的含量。结果 PET材料的药用滴眼剂瓶密封性最好，PP材料的次之，LDPE材料的密封性相对最差，不利于复方滴眼液的保存。结论 复方西瓜霜滴眼液适合选择密封性相对较好的聚酯、聚丙烯材料作为外包装材料。

Objective To determine the effects of different plastic packaging materials on the main components in Compound Mirabilitum Praeparatum Eye Drops. Methods The retention samples were put at the room temperature (25 ℃±2 ℃) and in the acceleration test (40 ℃±2 ℃). The contents of citrulline, natural borneol, and ethanol in Compound Mirabilitum Praeparatum Eye Drops packaged respectively by low density polyethylene (LDPE), polypropylene (PP), and polyester (PET), which were stored for 0－3, and 6 months, were determined by HPLC and GC. Results The bottle sealing by PET is best, followed by PP. LDPE is the worst and not conducive to be preserved in it. Conclusion PET and PP are suitable to use as the packages of Compound Mirabilitum Praeparatum Eye Drops.