目的 研究复方鸦胆子油脂质体冻干粉的性质，建立其质量评价方法。方法 考察复方鸦胆子油脂质体的形态、粒径分布、Zeta电位，采用TLC法对其定性鉴别，并采用溶剂萃取法测定脂质体包封率。同时，通过UV和GC的方法测定其有效成分的含量。结果 复方鸦胆子油脂质体冻干粉色泽均匀，质地细腻，形态饱满，其平均粒径为170.3 nm，多分散系数（PDI）为0.258，Zeta电位为?32.1 mV，带负电，脂质体pH为5.05。TLC鉴别中检出蟾酥、鸦胆子油斑点清晰可见。脂质体冻干粉的平均包封率为91.90%，吲哚类生物碱的平均质量分数为5.19 mg/g，油酸的平均质量分数为79.08 mg/g，亚油酸的平均质量分数50.41 mg/g。脂质体的平均过氧化值为0.030 5。结论 上述方法适用于复方鸦胆子油脂质体冻干粉的质量评价，可有效反映其各方面的性质。

Objective To study the properties of liposomes freeze-powder of compound Brucea Javanica oil (LFP-CBO), and to establish the quality evaluation methods. Methods The form, particles distribution, and Zeta potential of LFP-CBO were investigated, TLC was used to identify the chemical composition, the encapsulation efficiency was determined by solvent extraction method, and the active ingredients was determined by UV and GC. Results The mean particle size of LFP-CBO was 170.3 nm with uniform color, fine texture, and round shape, and the polydisperse index (PDI) was 0.258. The Zeta potential was ?32.1 mV with negative charge, and the pH value was 5.05. The spots of B. Javanica and Veneum Bufonis were clear on TLC. The average encapsulation efficiency of the optimal formulation was 91.9%. The concentration of indole alkaloids, oleic acid, and linoleic acid was 5.19, 79.08, and 50.41 mg/g, and the peroxide value of LFP-CBO was 0.030 5. Conclusion The methods above are suitable for the quality evaluation of LFP-CBO, and could effectively demonstrate its properties.