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[摘要]
目的 探讨抗痨复肝胶囊对实验动物的止咳祛痰、保肝复肝作用。方法 采用氨水引咳法、气管酚红排泄法观察抗痨复肝胶囊的止咳祛痰作用;采用异烟肼和利福平制作肝损伤模型,检测肝脏指数及AST和ALT的含量,并观察各组小鼠肝组织的病理学改变。结果 抗痨复肝胶囊能够显著减少小鼠的咳嗽次数、增加小鼠气道酚红排泄量;各给药组小鼠肝脏指数和血清中ALT和AST水平显著降低,与模型组比较具有统计学意义(P<0.05、0.01),给药组小鼠肝组织损伤有明显的逆转。结论 抗痨复肝胶囊有显著的止咳祛痰作用,对利福平和异烟肼所致的肝组织损伤也有显著的保护作用。
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[Abstract]
Objective To investigate the effect such as antitussive, expectorant, protecting hepatic function of Kanglao Fugan Capsule. Methods The antitussive and expectorant effect on cough model of mice were investigated by ammonia liquor and phenol red excretion. As hepatic injury model by isoniazid and rifampicin, the liver indexes of mice, AST and ALT levels, were detected,. At same time we observed the pathological changes in liver tissues of mice. Results Kanglao Fugan Capsule could significantly reduce the frequency of cough of mice and increase the airway phenol red excretion. Compared with the model group, the liver indexes of mice, ALT and AST content in serum of mice in drug group were significantly decreased,with statistical significance (P < 0.05 or P < 0.01). The liver tissue injury of drug treated mice was significantly reversed. Conclusion Kanglao Fugan Capsule not only has the antitussive and expectorant effect, but also has the significant protection on liver injury induced by rifampin and isoniazid.
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