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[摘要]
目的 探讨杜仲多糖对兔心肌缺血再灌注损伤的保护作用。方法 将兔随机分为4组(每组8只),即假手术组、缺血再灌注组、丹参片预处理组、杜仲多糖预处理组。监测各组兔血清心肌酶谱、超氧化物歧化酶(SOD)、丙二醛(MDA)等水平的变化。结果 杜仲多糖预处理组心肌酶、SOD、MDA含量与缺血再灌注组、丹参预处理组比较差异显著(P<0.05)。结论 杜仲多糖对兔心肌缺血再灌注损伤能够产生较好的保护作用。
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[Abstract]
Objective To demonstrate the effect of Eucommia ulmoides polysaccharides (EUP) on rabbit myocardial ischemia- reperfusion injury model. Methods Rabbits were divided into four groups including Sham group, ischemia-reperfusion group, groups pretreated with Salvia miltiorrhiza and EUP. And the indexes of CK, CK-MB, LDH, AST, SOD, and MDA were detected. Results Results showed that those indexes in group pretreated with EUP differed significantly from other groups (P < 0.05). Conclusion It shows that EUP may decrease the injury of myocardial ischemia-reperfusion so as to get the better protection of rabbits.
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