[关键词]
[摘要]
目的 建立生理盐水注射液中双酚A(BPA)残留量的测定方法。方法 采用气相色谱-三重四级杆(GC-TQ-MS/MS)联用技术,测定了5批生理盐水注射液中BPA的残留量,每批平行测定6次,且每次分别在5、10、20 μg/kg 3个添加水平下进行加样回收,每水平分别测定3次。结果 所测5批生理盐水注射液中BPA质量分数分别为27.01、11.80、15.73、22.28、9.03 μg/kg;RSD分别为2.3%、4.2%、3.2%、4.4%、1.9%;平均加样回收率在79.9%~99.3%,RSD均小于4.1%。BPA在10~200 μg/L内呈良好的线性关系,检测限为1.25 μg/kg。结论 该法简便快速、灵敏性高,可用于生理盐水注射液中BPA残留量的测定。
[Key word]
[Abstract]
Objective To establish a GC-TQ-MS/MS method for the determination of bisphenol A (BPA) in physiological saline injection (PSI). Methods The determination of BPA remaining in five batches of PSI with six parallel tests for each batch. Spiked recovery rates were determined in added levels at 5, 10, and 20 μg/kg for three times in each level. Results The contents of BPA in five batches of PSI were 27.01, 11.80, 15.73, 22.28, and 9.03 μg/kg, respectively, with RSD values of 2.3%, 4.2%, 3.2%, 4.4%, and 1.9%. The average recovery rates were between 79.9% and 99.3% with RSD values less than 4.1%. There was a good liner relationship in the range of 10—200 μg/L for BPA and the limit of detection (LOD) was 1.25 μg/kg. Conclusion The method is simple, rapid, accurate and repeatable, and can be used to measure the content of BPA in PSI with high sensitivity.
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[基金项目]
江苏出入境检验检疫局项目(2011KJ48);镇江市科技支撑计划(SH2012010)