Markov模型于20世纪80年代用于医学领域，目前已成为药物经济学评价中最常用的方法之一，且前景广阔。国内利用Markov模型进行药物经济学评价虽然相比于国外起步较晚，但发展速度不断加快，差距日渐缩小，评价方案逐步实现正规化。查阅近5年国内外相关文献，围绕模型建立与参数设定、设立对照、不确定性分析以及评价结果这4个基本流程，简述国内外学者利用Markov模型进行药物经济学评价的研究进展，并指明该方法的不足之处。

The Markov model was used in the medicinal field in the 1980s. It has become one of the most commonly used method in pharmaco-economics and it also has broad prospects. The use of Markov model in pharmaco-economics in China started later than aboard. However, the pace of development continues to be accelerated and the gap is shrinking. The evaluation program is being gradually normalized. To search the related literature in the last five years and around modeling establishment, the parameter settings, the uncertainty analysis, and the evaluation results of these four basic processes, the research progress of domestic and foreign scholars who use Markov model for pharmaco-economics evaluation are summarized and the shortcomings of this method are indicated.