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[摘要]
甘草酸对出血性、缺血性或缺血-再灌注性脑损伤、缺血-再灌注性脊髓损伤以及化学品造成的神经损伤有显著的保护作用,也能改善脑缺血性痴呆大鼠的学习记忆功能。综述了甘草酸、甘草次酸、甘草酸二铵、甘珀酸对脑损伤的保护作用以及改善学习记忆功能的药理作用研究进展。认为甘草酸的脑保护作用可能是其抗炎、抗氧化、抗细胞凋亡、抗胆碱酯酶和温和的糖皮质激素样作用等基本药理作用综合的结果。
[Key word]
[Abstract]
Glycyrrhizic acid has significantly protective effects on hemorrhagic, ischemic, ischemic-reperfusion encephalic injury, ischemic-reperfusion spinal cord injury, and chemicals-induced neuron damage, and improves the performance of learning and memory of rats with ischemic dementia. In this paper, the advances in pharmacologic studies on glycyrrhizic acid, glycyrrhetinic acid, diammonium glycyrrhizinate, and carbenoxolone in the protection of encephalic injury and the improvement of memory are reviewed. It is suggested that the encephalic protection of glycyrrhizic acid is a comprehensive result of the basic actions with anti-inflammatory, anti-oxidative, anti-apoptosis, anti-cholinesterase, and moderate glucocorticoid-like effects.
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