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[摘要]
近年来,脑缺血的炎症反应引起了越来越多学者的关注。炎症反应是缺血性脑损伤的重要病理生理机制之一,参与缺血性脑卒中的发生、发展,与危及生命的并发症相关,从而构成了缺血性损伤的基础。就脑缺血有关的炎性因子及以白细胞介素(IL)-1、IL-8、IL-10、细胞间黏附分子(ICAM)-1、肿瘤坏死因子(TNF)-α和黑皮质素(MC)4为靶点的抗脑缺血药物的最新研究进展作一综述。
[Key word]
[Abstract]
In recent years, the inflammatory reaction of cerebral ischemia has attracted more and more attention of the scholars. Inflammation is one of the important pathophysiological mechanisms of ischemic brain damage, which is involved in the occurrence and development of ischemic stroke and relative with life-threatening complication accompanying ischemic stroke. Additionally, inflammatory factors produced by cerebral ischemia constitute the basis of ischemic injury. This review summarizes the latest research development of some kinds of inflammatory factors related to cerebral ischemia and IL-1, IL-8, IL-10, ICAM-1, TNF-alpha and MC4 as a target for anti-cerebral ischemic drug.
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