黑色素瘤由于转移性强，成为皮肤癌中死亡率最高的恶性肿瘤之一，目前没有有效的治疗方法。凝血酶蛋白酶激活受体-1（PAR-1）在黑色素瘤的发病过程中起到重要作用，PAR-1通过激活肿瘤细胞黏附和侵袭以及新生血管因子生成促进黑色素瘤转移。PAR-1有望成为治疗转移性黑色素瘤药物新靶点。

Melanoma remains as the deadliest form of skin cancer with limited and inefficient treatment options available for patients with metastatic disease. The thrombin receptor, Protease Activated Receptor-1, has been considered to play an important role in the progression of human melanoma. PAR-1 is known to activate adhesive, invasive and angiogenic factors to promote melanoma metastasis. This review is about the advance in the research of PAR-1as a potential target of metastatic melanoma.

国家重大新药创制专项（2011ZX09401-009）；天津市科技支撑计划重点项目（10ZCKFSH01300）