目的 建立安多霖胶囊内容物的红外光谱和HPLC指纹图谱，考察喷雾干燥与微波干燥对安多霖胶囊内容物的影响。方法 分别对安多霖配方提取液选择喷雾干燥、微波干燥两种方法，制备8批供试品，绘制8批粉体的红外光谱图，采用高效液相色谱法，梯度洗脱绘制不同粉体溶液的HPLC指纹图谱，比较不同干燥方法所得粉体的图谱，评价不同干燥工艺的优劣。结果 安多霖胶囊配方提取液经喷雾干燥和微波干燥后，其红外光谱和HPLC指纹图谱极其相似，不同干燥工艺没有引起安多霖胶囊物质基础的改变。结论 不同干燥工艺所得安多霖胶囊内容物的物质种类和总量极其相似，两种干燥方法均可应用于安多霖胶囊配方提取液的干燥。

Objective To establish infrared (IR) spectrum and HPLC fingerprint for the content of Anduolin Capsules (AC) and to investigate the effect of spray drying and microwave drying technologies on the content of AC. Methods Spray drying and microwave drying were used on AC preparation. Eight batches of AC powder were prepared, and the IR spectrograms were drawn. The HPLC fingerprint of different powder solutions was drawn using gradient elution, and the spectra of powders dried by various technologies were compared and evaluated. Results The IR spectrum and HPLC fingerprint of extracting solution from AC dried by various technologies were very similar, and the various drying technologies did not change the material basis in content of AC. Conclusion The content of AC dried by various technologies is extremely similar in material type and amount, and the two drying methods could be applied in AC extract.

福建省自然科学基金计划项目（2009J01116）；福建省卫生厅青年科研项目（2009-1-38）；福建省医学科学研究院院立项目（2008-03）