目的 研究氧诱导视网膜新生血管小鼠模型中视网膜血管内皮细胞生长因子（VEGF）与视网膜新生血管的相关性。方法 通过建立氧诱导视网膜新生血管小鼠模型，分别于12、14、17、21 d龄随机抽取2组幼鼠各6只，一侧眼球测定视网膜VEGF水平，另一侧眼球进行视网膜铺片、ADP酶染色，考察其相关性。结果 模型组小鼠左眼球ADP酶染色结果显示，模型组12 d龄小鼠血管迂曲、扩张、变形，随时间延长血管变形加重，17 d时最严重，且视乳头周围出现大片无灌注区，视网膜周边可见大量新生血管生成，到21 d时模型开始恢复。视网膜VEGF测定结果显示，12 d龄模型小鼠VEGF开始升高，17 d达峰值，以后下降。结论 视网膜VEGF变化和视网膜血管形态具有很好的正相关性，17 d时新生血管形成最多。

Objective To study the correlation between retinal vascular endothelial growth factor (VEGF) level and retinal neovascularization in oxygen-induced retinal neovascularization model of mice. Methods The oxygen-induced retinal neovascularization model of mice was established and two groups of six mice for each group were randomly selected at 12, 14, 17, and 21 d age, respectively. The retinal VEGF in one side of the eyeballs was detected, the retinal sect serial sections and ADPase staining were carried out in the other side of the eyeballs, and the relevance was studied. Results In the model group, ADPase staining showed a pattern of pathological retinal neovascularization such as tortuous, dilated, and deformed blood vessels at 12 d age, and the deformation was aggravated with time. The most serious deformation was at 17 d age, and there were large nonperfused areas around discus opticus. A large number of new blood vessels were generated visibly in the peripheral retinal areas and the model began to recover at 21 d age. The retinal VEGF levels started to increase at 12 d age, reached the peak at 17 d age, and declined after that. Conclusion The retinal VEGF levels and the retinal vascular morphology have a positive correlation and neovascularization is the most serious at 17 d age.