[关键词]
[摘要]
近年来,毒理基因组学的快速发展为生物标志物的研究提供了一个更广阔的空间。生物标志物作为一种可以客观衡量和评价正常生理、病理过程及治疗药物药理学效应的指标,如今已被广泛应用于临床诊断和新药开发等多个领域。就毒理基因组学在发现和筛选生物标志物方面的研究现状和进展进行综述。
[Key word]
[Abstract]
Toxicogenomics has recently been developed greatly, and it has contributed a lot on identifying potential biomarkers of toxicity. Biomarker is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, and pharmacologic responses to a therapeutic intervention. Nowadays, biomarkers have already been used widely at clinical diagnosis and investigation of new drugs. The progression of application of toxicogenomics on discovery and Screening of biomarker is reviewed.
[中图分类号]
[基金项目]
中国食品药品检定研究院中青年发展研究基金(2011C3)