[关键词]
[摘要]
ATP结合盒转运体(ABC转运体)介导的多药耐药(MDR)是肝癌化疗失败的主要原因,研究确定天然的及获得性MDR的产生机制,有利于提出更有效的治疗措施。针对ATP结合盒转运体的肿瘤MDR逆转策略,对于肝癌化疗效果的提高具有重要意义。此外,ATP结合盒转运体可能参与了肿瘤生物学的一些重要过程,发挥药物外排泵以外的作用,为肿瘤的治疗提供了新的研究方向。
[Key word]
[Abstract]
The failure of chemotherapy in liver cancer treatment often occurs as a result of multidrug resistance (MDR) mediated by ATP-binding cassette (ABC) transporters and the development of more effective therapies depends on identifying the mechanisms of intrinsic or acquired MDR. Strategies focused on ABC transporters to overcome MDR have a lot of benefits on the chemotherapy of liver cancer. Furthermore, considerable evidence suggests that the ABC transporters play a fundamental role in tumor biology beyond the efflux of cytotoxic drugs, which indicates a new way of study on cancer therapy.
[中图分类号]
[基金项目]
国家自然科学基金项目(81072694, 30873118)