[关键词]
[摘要]
Lipinski规则是药物分子设计和药物筛选常用的规则之一。从口服和非口服药物两个方面举例说明它的效用,同时指出它在非口服药物中的局限性和口服药物中发展的前景,旨在为能够正确认识和恰当使用该原则提供参考。
[Key word]
[Abstract]
Lipinski’s rule is one of the common rules for drug molecular design and compound screening. This review summarizes the applications of theses rules in oral and non-oral drugs, on where their shortcomings in non-oral drugs and their prospect in oral drugs are pointed out simultaneously for the purpose of its being comprehended correctly and being used efficiently.
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