[关键词]
[摘要]
中药药动学研究是中药现代化研究链条的重要组成部分,在创新中药及现代复方中药研发中发挥着极其重要的作用,但目前尚缺乏符合中药自身特点的药动学研究方法。概述现有中药药动学研究现状,提出了中药复方“总量”药动学的概念,以期能够起到抛砖引玉的作用,共同促进中药药动学研究水平的提高。
[Key word]
[Abstract]
The pharmacokinetic study on Chinese materia medica (CMM) is an inalienable part of the chain in CMM modernization and plays an important role in the research and development of CMM novel drug and modern CMM formulae. However, nowadays the researching method and system that are consistent with the specific characteristics of CMM, i.e., multiple-components and targets, is still lacking. This review makes a brief summary of our recent developments on the pharmacokinetic exploration of CMMs. A tentative idea about the “total amount” pharmacokinetics of CMM has been proposed in order to promote its pharmacokinetic development.
[中图分类号]
[基金项目]
“重大新药创制专项”中药复方释药系统技术平台项目(2009ZX09310-005);“十一五”科技支撑计划项目(2006BA109B08-01);江西省卫生厅中医药科研项目(2009A061,2009A059)