[关键词]
[摘要]
抗肿瘤药物可注射植入型水凝胶是一种用于肿瘤局部用药的新型控释系统。根据凝胶材料的不同以及各个实验室的具体条件,对该系统的药理学评价方法有许多种。这些方法大致分为3类,包括生物相容性(安全性)评价、细胞毒性(药效学)评价和药动学评价。综述该系统药理学评价方法学研究的近况,为进一步研究和应用提供参考。
[Key word]
[Abstract]
The injectable implant hydrogel formulated antineoplastic agents exhibits a new delivery system for controlling to release in localized cancer therapy. According to the differences of gel materials and specific conditions in each laboratory, many evaluative methods for pharmacology are designed to the system. The methods can be approximately divided into three classes, biocompatible (security), cytotoxic (pharmacodynamics), and pharmacokinetic evaluations. The updated evaluative methods have been reviewed in this paper.
[中图分类号]
[基金项目]
国家高技术研究发展“863”计划(2009AA03Z313)