[关键词]
[摘要]
自胰岛素首次用于治疗糖尿病以来,随着对糖尿病病理生理和发病机制认识的深入,胰岛素的应用越来越广泛。综述近年来相关文献中有关胰岛素及其类似物制剂的分类、给药途径、体内吸收代谢、临床应用和不良反应等方面内容,为进一步研究、开发和合理利用胰岛素及其类似物提供参考。
[Key word]
[Abstract]
Since the first time insulin used in the treatment of diabetes, and with the development of pathophysiology and pathogenesis in diabetes, insulin has been gaining a widely usage. For the future research, development and rational utilization of insulin, this paper reviews recent literature relating to classification, administrations, absorption, metabolism, clinical applications, adverse reactions of insulin and its analogues.
[中图分类号]
[基金项目]
国家科技支撑计划项目(2007BAI41B04),“重大新药创制”科技重大专项(2008ZX09305-005),天津创新药物安全评价技术平台建设