目的：研究大鼠sc PTH（1-34）的药动学特征。方法：用¹²⁵I标记PTH（1-34）示踪法对大鼠sc PTH（1-34）后的血清药物浓度进行了测定，并用3P97程序拟和分析并计算药动学参数，采用超滤离心的方法进行药物与血浆蛋白结合率的研究。结果：大鼠sc PTH（1-34）10、20和40 μg/kg后，药物消除符合一房室模型。平均t_1/2ke为（0.92±0.04）h；平均CL为（0.56±0.05）L/（kg·h）；C_max和AUC_{0-8 h}均与剂量呈线性正相关，不同剂量药物与血浆蛋白平均结合率为13.4％。结论：大鼠sc PTH（1-34）后，药物消除符合线性动力学特征。

Objective: To study the pharmacokinetic characteristics on parathyroid hormone (PTH, 1-34) after sc injection in rats. Methods: Serum drug concentration was measured by ¹²⁵I labeled method after sc injection in rats, the pharmacokinetic model and parameters were fitted and calculated by the 3P97 program. Results: After sc injection at doses of 10, 20, and 40 μg/kg in rats, the serum drug concentration-time curve was fitted to a one-compartment model. Mean t_1/2ke was (0.92 ± 0.04) h and mean CL was (0.56 ± 0.05) L/(kg·h). The C_max and AUC_{0-8 h} were positive linear correlation with the dose. Mean binding ratio of various doses drug with plasma protein was 13.4%. Conclusion: After sc injection of PTH (1-34) to rats, the elimination of PTH (1-34) could fit to the linear kinetics.

国家科技支撑计划（2007BAI14IB04）