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[摘要]
目的:介绍壳聚糖微/纳米粒在新型定向给药系统中的应用,为发展安全高效的壳聚糖微/纳米粒定向给药系统提供参考。方法:综合近年来出版的有关文献,对壳聚糖基本性质,定位给药于各组织部位进行了探讨。结果:壳聚糖微/纳米粒可应用于脑、眼、鼻、口、肺、胃、小肠、结肠等器官靶向给药。结论:壳聚糖微/纳米粒作为一种新型药用辅料,在定位给药系统中已经得到了开发和应用。
[Key word]
[Abstract]
Objective: Chitosan micro / nano particles in novel targeted drug delivery system were reviewed to provide reference in development of safe and efficient chitosan micro / nano particles targeting drug delivery system. Methods: According to the literature published in the recent years, the basic nature of chitosan and it’s targeted drug delivery in various tissues were discussed. Results: Chitosan micro / nano particles can be applied to brain, ophthalmic, nasal, buccal, pulmonary, stomach, small intestine, colon and other organs targeted drug delivery. Conclusion: Chitosan micro / nano particles, as a kind of novel pharmaceutical excipient, have been developed and applied in targeted drug delivery system.
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