心肌缺血是导致心肌梗死的主要原因，还可继发心肌缺血再灌注损伤。黄芪甲苷是黄芪干燥根中提取的四环三萜皂苷类化合物，具有多种活性，通过降低心肌细胞凋亡、降低氧化应激反应、降低心肌炎性损伤、延缓心肌重塑、抑制过度细胞自噬、维持内源性能量代谢、促进新生血管形成减轻心肌缺血再灌注损伤。总结了黄芪甲苷对心肌缺血再灌注损伤保护作用的研究进展，为黄芪甲苷的临床运用提供参考。

Myocardial ischemia is the main cause of myocardial infarction and can also lead to secondary myocardial ischemia-reperfusion injury. Astragaloside IV is a tetracyclic triterpenoid saponin compound extracted from dried roots of Astragali Radix, which has various activities. Astragaloside IV can alleviate myocardial ischemia-reperfusion injury by reducing myocardial cell apoptosis, lowering oxidative stress response, reducing myocarditis injury, delaying myocardial remodeling, inhibiting excessive cell autophagy, maintaining endogenous energy metabolism, and promoting neovascularization. This article summarizes the research progress on the protective effect of astragaloside IV against myocardial ischemia-reperfusion injury, providing reference for the clinical application of astragaloside IV.

R285.5;R972