目的 探讨白芍总苷胶囊联合硫酸羟氯喹片治疗口腔扁平苔藓的临床疗效。方法 将2023年3月—2025年2月在自贡市第一人民医院就诊的80例口腔扁平苔藓患者纳入研究，按随机数字表法分为对照组和治疗组，每组40例。对照组口服硫酸羟氯喹片，2次/d，2片/次。治疗组在对照组基础上口服白芍总苷胶囊，3次/d，2粒/次，两组持续治疗2个月。比较两组的临床疗效、糜烂面积、疼痛程度、生活质量、血清指标和淋巴细胞。结果 治疗组总有效率为97.50%，对照组总有效率为82.50%，组间比较差异有统计学意义（P＜0.05）。两组治疗后的糜烂面积、视觉模拟量表（VAS）评分、口腔健康影响程度量表（OHIP）-14评分明显降低（P＜0.05），且治疗组的糜烂面积、VAS评分、OHIP-14评分低于对照组（P＜0.05）。两组患者治疗后的血清可溶性程序性死亡受体l（sPD-L1）、白细胞介素-12（IL-12）、白细胞介素-17（IL-17）水平显著降低（P＜0.05），且治疗组的血清sPD-L1、IL-12、IL-17水平较对照组更低（P＜0.05）。两组治疗后的Treg显著升高，Th17、Th17/Treg显著降低（P＜0.05）；治疗组治疗后的Treg高于对照组，Th17、Th17/Treg低于对照组（P＜0.05）。结论 白芍总苷胶囊联合硫酸羟氯喹片可提高口腔扁平苔藓的疗效，降低疼痛程度和糜烂面积，减轻炎症反应和调节免疫功能。

Objective To investigate the clinical efficacy of Total Glycosides of White Peony Capsules combined with Hydroxychloroquine Sulfate Tablets in treatment of oral lichen planus. Methods 80 Patients with oral lichen planus who received treatment in Zigong First People’s Hospital from March 2023 to February 2025 were included in the study and were divided into control group and treatment group using a random number table method, with 40 patients in each group. The control group took Hydroxychloroquine Sulfate Tablets orally, twice daily, two tablets each time. On the basis of the control group, patients in the treatment group took Total Glycosides of White Peony Capsules orally, three times daily, 2 capsules per time. Two groups were evaluated for treatment efficacy after completing 2 months of continuous treatment. The clinical efficacy, erosion area, pain level, quality of life, serum indicators, and lymphocytes were compared between two groups. Results The total effective rate of the treatment group was 97.50%, while the total effective rate of the control group was 82.50%, and the difference between the groups was statistically significant (P < 0.05). The erosion area, Visual Analog Scale (VAS) score, and Oral Health Impact Scale (OHIP) -14 score of the two groups after treatment were significantly decreased (P < 0.05), and the erosion area, VAS score, and OHIP-14 score of the treatment group were lower than those of the control group (P < 0.05). The serum levels of sPD-L1, IL-12, and IL-17 of two groups of patients after treatment were significantly reduced (P < 0.05), and the serum levels of sPD-L1, IL-12, and IL-17 in the treatment group were lower than those in the control group (P < 0.05). After treatment, the levels of Treg in both groups were significantly increased, while the levels of Th17 and Th17/Treg were significantly decreased (P < 0.05). The levels of Treg in the treatment group were higher than those in the control group after treatment, while Th17 and Th17/Treg levels were lower than those in the control group (P < 0.05). Conclusion The combination of Total Glycosides of White Peony Capsules and Hydroxychloroquine Sulfate Tablets can improve the efficacy of oral lichen planus, reduce pain and erosion area, alleviate inflammatory response, and regulate immune function.

R988.2

自贡市卫生健康系统科研（24yb068）