目的 探讨裸花紫珠颗粒联合糠酸莫米松鼻喷雾剂治疗变应性鼻炎的临床疗效。方法 选择2023年5月—2024年5月在青岛市城阳区人民医院诊治的变应性鼻炎患者108例，依据随机数字表法分为对照组和治疗组，每组各54例。对照组患者给予鼻喷糠酸莫米松鼻喷雾剂，每次每只鼻孔2揿，1次/d，症状明显缓解后更改为每次每只鼻孔1揿，1次/d。治疗组患者在对照组治疗方案基础上口服裸花紫珠颗粒，1袋/次，3次/d。两组患者均接受4周治疗。观察两组患者临床疗效，比较治疗前后两组患者鼻伴随症状总分表（TNNSS）和鼻炎生活质量问卷（RQLQ）评分，鼻腔分泌物骨膜蛋白（POSTN）、白细胞介素-13（IL-13）和嗜酸性细胞阳离子蛋白（ECP）水平，以及3、6个月的复发率。结果 治疗后，治疗组总有效率（96.30%）明显高于对照组（85.19%，P＜0.05）。治疗后，两组TNNSS评分和RQLQ评分较治疗前明显下降（P＜0.05），且治疗组评分下降幅度显著高于对照组（P＜0.05）。治疗后，两组患者鼻腔分泌物POSTN、IL-13和ECP水平较治疗前明显降低（P＜0.05），且治疗组患者的下降幅度显著高于对照组（P＜0.05）。治疗组患者疗程结束后3、6个月的复发率明显低于对照组（P＜0.05）。结论 裸花紫珠颗粒联合糠酸莫米松鼻喷雾剂治疗变应性鼻炎疗效显著，不仅能够显著降低鼻腔分泌物相关指标水平和复发率，而且能改善患者鼻部症状和生活质量。

Objective To explore the clinical efficacy of Luohua Zizhu Granules combined with mometasone furoate aqueous in treatment of allergic rhinitis. Methods Patients (108 cases) with allergic rhinitis in Chengyang District People's Hospital from May 2023 to May 2024 were divided into control and treatment group according to random number table method, and each group had 54 cases. Patients in the control group were administered with Mometasone Furoate Aqueous Nasal Spray, 2 presses for each nostril once, and changed to 1 press for each nostril once after symptoms were significantly relieved, once daily. Patients in the treatment group were po administered with Luohua Zizhu Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical evaluations were evaluated, and the scores of TNNSS and RQLQ, the levels of POSTN, IL-13 and ECP of nasal secretions, the recurrence rates of 3 and 6 months after treatment in two groups before and after treatment were compared. Results After treatment, the total effective rate in the treatment group (96.30%) was significantly higher than that in the control group (85.19%, P < 0.05). After treatment, the TNNSS score and RQLQ score in two groups were significantly decreased compared with before treatment (P < 0.05), and the scores decrease in the treatment group was significantly higher than that in the control group (P < 0.05). After treatment, the levels of POSTN, IL-13 and ECP of nasal secretions in two groups were significantly lower than those before treatment (P < 0.05), and the decrease in the treatment group was significantly higher than that in the control group (P < 0.05). The recurrence rates at 3 and 6 months after the end of the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion The combination therapy of Luohua Zizhu Granules and mometasone furoate aqueous for allergic rhinitis is significantly effective, not only significantly reducing the levels of nasal secretion-related indicators and recurrence rates, but also improving patients' nasal symptoms and quality of life.

R976

山东省医药卫生科技发展计划项目（2022WS0059）