[关键词]
[摘要]
纤维化是指机体受到各种因素刺激,多种纤维化相关信号通路被激活并共同介导,引起胶原蛋白、纤维连接蛋白、蛋白多糖、弹力蛋白等沉积导致靶器官和组织结构异常的过程。TGF-β1/Smads是公认的在纤维化过程中起关键调控作用的信号通路。研究发现紫杉醇能通过抑制TGF-β1/Smads信号通路而发挥抗纤维化作用。主要对紫杉醇在多种纤维化疾病中应用的研究进展进行综述。
[Key word]
[Abstract]
Fibrosis refers to the process in which the body is stimulated by various factors and various fibrosis-related signal pathways are activated and jointly mediated to cause the deposition of collagen, fibronectin, proteoglycan, elastin, and other proteins, resulting in the abnormal structure of target organs and tissues.TGF-β1/Smads is a recognized signaling pathway that plays a key regulatory role in the fibrosis process. Recent studies have shown that paclitaxel acts as an anti-fibrotic agent by inhibiting the TGF-β1/Smads signaling pathway. The recent research progress on application of paclitaxel in a variety of fibrosis disease are reviewed in this article.
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