目的 探讨维U颠茄铝胶囊Ⅱ联合奥美拉唑肠溶胶囊治疗胃溃疡的临床疗效。方法 选取2016年3月—2018年3月天长市人民医院收治的82例胃溃疡患者为研究对象，按照随机数字表法将所有患者随机分为对照组和治疗组，每组各41例。对照组于早餐前0.5 h整粒吞服奥美拉唑肠溶胶囊，1粒/次，1次/d。治疗组在对照组治疗的基础上于每餐后0.5 h口服维U颠茄铝胶囊Ⅱ，1粒/次，3次/d。两组均连续治疗6周。观察两组的临床疗效，比较两组的症状积分、溃疡面积、胃液酸碱度（pH）值、血清因子水平、复发情况和幽门螺杆菌根除率。结果 治疗后，对照组和治疗组的疾病总有效率分别为78.0%、95.1%，两组比较差异有统计学意义（P<0.05）。治疗后，对照组和治疗组的胃镜总有效率分别为80.5%、97.6%，两组比较差异有统计学意义（P<0.05）。治疗后，两组中上腹痛、反酸、恶心、纳差、腹胀、厌食、胃灼烧积分和总分均显著减少，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗后治疗组各项主要症状积分均明显低于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组溃疡面积均显著缩小，胃液pH值显著上升，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗后治疗组溃疡面积、胃液pH值明显优于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组血清白细胞介素（IL）-6、IL-8水平均显著降低，表皮生长因子（EGF）、血管内皮生长因子（VEGF）水平均显著升高，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组血清因子水平明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，对照组和治疗组幽门螺杆菌根除率分别为70.7%、90.2%，两组比较差异有统计学意义（P<0.05）。随访6个月，对照组和治疗组复发率分别为19.5%、4.9%，两组比较差异有统计学意义（P<0.05）。结论 维U颠茄铝胶囊Ⅱ联合奥美拉唑肠溶胶囊治疗胃溃疡具有较好的临床疗效，能减轻患者胃肠道症状，上调胃内pH值，提高幽门螺杆菌根除率，抑制机体炎症反应，促进溃疡愈合，降低复发风险，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Vitamin U, Belladonna and Aluminium Capsules Ⅱ combined with Omeprazole Enteric-coated Capsules in treatment of gastric ulcer. Methods Patients (82 cases) with gastric ulcer in Tianchang People's Hospital from March 2016 to March 2018 were randomly divided into control and treatment groups, and each group had 41 cases. Patients in the control group were po administered with Omeprazole Enteric-coated Capsules before breakfast of 0.5 h, 1 grain/time, once daily. Patients in the treatment group were po administered with Vitamin U, Belladonna and Aluminium Capsules Ⅱ on the basis of the control group, 1 grain/time, three times daily. Patients in two groups were treated for 6 weeks. After treatment, the clinical efficacies were evaluated, and symptom scores, ulcer area, gastric juice pH value, serum factor levels, recurrence rate, and Helicobacter pylori eradication rate in two groups were compared. Results After treatment, the therapeutic efficacies in the control and treatment groups were 78.0% and 95.1%, respectively, and there was difference between two groups (P<0.05). After treatment, the gastroscopic efficacies in the control and treatment groups were 80.5% and 97.6%, respectively, and there was difference between two groups (P<0.05). After treatment, mid-upper abdominal pain score, acid reflux score, nausea score, nausea score, abdominal distension score, anorexia score, heartburn score, and total score in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the ulcer areas in two groups were significantly decreased, but the gastric juice pH value in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of IL-6 and IL-8 in two groups were significantly decreased, but the levels of EGF and VEGF in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serum factor levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the Helicobacter pylori eradication rates in the control and treatment groups were 70.7% and 90.2%, respectively, and there was difference between two groups (P<0.05). Follow-up for 6 months, the recurrence rates in the control and treatment groups were 19.5% and 4.9%, respectively, and there was difference between two groups (P<0.05). Conclusion Vitamin U, Belladonna and Aluminium Capsules Ⅱ combined with Omeprazole Enteric-coated Capsules has clinical curative effect in treatment of gastric ulcer, can alleviate gastrointestinal symptoms, increase gastric pH value, increase eradication rate of Helicobacter pylori, inhibit inflammation, promote ulcer healing, and reduce recurrence risk, which has a certain clinical application value.