目的 探讨骨力胶囊联合鲑降钙素注射液治疗老年骨质疏松症的临床疗效。方法 选取2016年3月—2018年3月三六三医院收治的骨质疏松症患者94例为研究对象，根据入院号的奇偶数分为对照组和治疗组，每组各47例。对照组皮下注射鲑降钙素注射液，50 IU/次，1次/d；治疗组在对照组治疗的基础上口服骨力胶囊，0.9 g/次，3次/d。两组均治疗8周。观察两组的临床疗效，比较两组的骨密度（BMD）、骨代谢指标、视觉模拟评分法（VAS）评分、Oswestry功能障碍指数问卷表（ODI）评分。结果 治疗后，对照组和治疗组的总有效率分别为80.85%、95.74%，两组比较差异有统计学意义（P<0.05）。治疗后，两组腰椎、股骨颈、股骨粗隆的BMD都明显增高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组腰椎、股骨颈、股骨粗隆的BMD明显高于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组血清β-胶原降解产物（β-CTX）、抗酒石酸酸性磷酸酶（TRACP）、骨碱性磷酸酶（BNALP）水平均显著下降，骨钙素（BGP）、25-羟维生素D[25-(OH) D]水平均显著增加，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组血清骨代谢指标水平明显优于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组VAS评分、ODI评分均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗后治疗组VAS评分、ODI评分明显低于对照组，两组比较差异有统计学意义（P<0.05）。结论 骨力胶囊联合鲑降钙素注射液治疗老年骨质疏松症具有较好的临床疗效，可缓解疼痛，增加BMD，改善骨代谢指标，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Guli Capsules combined with Salmon Calcitonin Injection in treatment of senile osteoporosis. Methods Patients (94 cases) with senile osteoporosis in AVIC 363 Hospital from March 2016 to March 2018 were randomly divided into control and treatment groups, and each group had 47 cases. Patients in the control group were subcutaneous injection administered with Salmon Calcitonin Injection, 50 IU/time, once daily. Patients in the treatment group were po administered with Guli Capsules on the basis of the control group, 0.9 g/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and BMD, bone metabolism indexes, VAS scores, and ODI scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.85% and 95.74%, respectively, and there was difference between two groups (P<0.05). After treatment, the BMD of Lumbar spine, femoral neck, and femoral trochanter in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the BMD in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of β-CTX, TRACP, and BNALP in two groups were significantly decreased, but the levels of BGP and 25-(OH) D in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the bone metabolism indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, VAS scores and ODI scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Guli Capsules combined with Salmon Calcitonin Injection has clinical curative effect in treatment of senile osteoporosis, can relieve pain, increase BMD, and improve bone metabolism, which has a certain clinical application value.