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[摘要]
目的 探索骨龙胶囊联合塞来昔布治疗类风湿性关节炎的临床效果。方法 选取2016年7月—2018年7月在海南医学院第一附属医院就诊的患者134例,随机分为对照组和治疗组,每组各67例。对照组患者口服塞来昔胶囊,0.1 g/次,2次/d;治疗组在对照组基础上口服骨康胶囊,4粒/次,3次/d;两组患者均治疗14 d。观察两组患者临床疗效,同时比较治疗前后两组患者症状改善情况、血沉状态、C-反应蛋白和类风湿因子水平。结果 治疗后,对照组临床有效率为65.67%,显著低于治疗组的79.10%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者临床症状较治疗前均显著改善(P<0.05),治疗组患者关节肿胀情况及晨僵时改善情况明显优于对照组(P<0.05),且治疗后治疗组症状改善情况明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血沉、C-反应蛋白和类风湿因子水平较均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗后治疗组生化因子水平明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 骨龙胶囊联合塞来昔布治疗类风湿性关节炎可获得较好的临床效果,且未增加不良事件发生情况。
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[Abstract]
Objective To explore the clinical effect of Gulong Capsules combined with celecoxib in treatment of rheumatoid arthritis. Methods Patients (134 cases) with rheumatoid arthritis in the First Affiliated Hospital of Hainan Medical College from July 2016 to July 2018 were randomly divided into control and treatment groups, and each group had 67 cases. Patients in the control group were po administered with Celecoxib Capsules, 0.1 g/time, twice daily. Patients in the treatment group were po administered with Gulong Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the improvement of clinical symptoms, erythrocyte sedimentation status, C-reactive protein and rheumatoid factor levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 65.67%, which was significantly lower than 79.10% in the treatment group, and there were differences between two groups (P<0.05). After treatment, clinical symptoms in two groups were significantly improved (P<0.05), the improvement of joint swelling and morning stiffness in the treatment group was significantly better than those in the control group (P<0.05). After treatment, the erythrocyte sedimentation status and C-reactive protein in control group were significantly improved (P<0.05), and these scores in the treatment group were significantly improved and better than those in the control group (P<0.05). Conclusion Gulong Capsules combined with celecoxib in treatment of rheumatoid arthritis can be used for the treatments of RA without increasing the incidence of adverse events.
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[基金项目]
国家自然科学基金资助项目(81460339)