[关键词]
[摘要]
目的 探究灯银脑通胶囊联合甲磺酸倍他司汀片治疗后循环缺血性眩晕的临床疗效。方法 选取2017年1月—2018年12月天津中医药大学第一附属医院治疗的120例后循环缺血性眩晕患者作为研究对象,将所有患者按随机数字表法分为对照组和治疗组,每组各60例。对照组患者口服甲磺酸倍他司汀片,6 mg/次,3次/d。治疗组患者在对照组的基础上口服灯银脑通胶囊,2粒/次,3次/d。两组患者均连续治疗14 d。观察两组患者的临床疗效,同时比较两组治疗前后的眩晕评定量表的评分系统(DARS)评分、眩晕障碍量表的筛查表(DHI-S)评分和椎基底动脉平均血流速度。结果 治疗后,对照组和治疗组的总有效率分别为71.67%、88.33%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者DARS、DHI-S评分均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗后治疗组的DARS、DHI-S评分明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者左椎动脉、右椎动脉、基底动脉平均血流速度均显著增快,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗后治疗组椎基底动脉平均血流速度均明显高于对照组,两组比较差异具有统计学意义(P<0.05)。结论 灯银脑通胶囊联合甲磺酸倍他司汀片治疗后循环缺血性眩晕临床疗效确切,可以有效减轻后循环缺血性眩晕的程度,调节血管舒缩功能,改善椎基底动脉平均血流速度,且安全性高,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To explore the clinical effect of Dengyin Naotong Capsules combined with Betahistine Mesilate Tablets in treatment of posterior circulation ischemic vertigo. Methods Patients (120 cases) with posterior circulation ischemic vertigo in First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from January 2017 to December 2018 were randomly divided into control and treatment groups by random number table method, and each group had 60 cases. Patients in the control group were po administered with Betahistine Mesilate Tablets, 6 mg/time, three times daily. Patients in the treatment group were po administered with Dengyin Naotong Capsules on the basis of control group, 2 grains/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the DARS scores, DHI-S scores, and the mean blood flow velocity of vertebrobasilar artery in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 71.67% and 88.33%, respectively, and there were differences between two groups (P<0.05). After treatment, DARS scores and DHI-S scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the DARS and DHI-S scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the mean blood flow velocity of left vertebral artery, right vertebral artery, and basilar artery in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the mean blood flow velocities of vertebrobasilar artery in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). Conclusion Dengyin Naotong Capsules combined with Betahistine Mesilate Tablets has definite clinical efficacy in treatment of posterior circulation ischemic vertigo, can effectively reduce the degree of posterior circulation ischemic vertigo, regulate vasomotor function, and improve the mean blood flow velocity of vertebrobasilar artery, with high safety, which has a certain clinical application value.
[中图分类号]
[基金项目]