[关键词]
[摘要]
目的 探讨丹红注射液联合脑苷肌肽注射液治疗急性脑梗死的临床疗效。方法 选择2016年3月—2018年3月在商洛市中心医院治疗的86例急性脑梗死患者为研究对象,两组患者依据治疗方法的不同分为对照组(45例)和治疗组(41例)。对照组静脉滴注脑苷肌肽注射液,20 mL加入到生理盐水250 mL中,1次/d。治疗组在对照组治疗的基础上静脉滴注丹红注射液,20 mL加入到生理盐水250 mL中,1次/d。两组患者均连续治疗14 d。观察两组的临床疗效,比较两组的美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力量表(ADL)评分、脑卒中专门化生存质量量表(SS-QOL)评分、氧化因子、促炎因子。结果 治疗后,对照组和治疗组的总有效率分别为80.00%、95.12%,两组比较差异有统计学意义(P<0.05)。治疗后,两组的NIHSS评分、ADL评分均显著降低,SS-QOL评分显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组各评分明显优于对照组,两组差异均有统计学意义(P<0.05)。治疗后,两组丙二醛(MDA)水平显著降低,超氧化物歧化酶(SOD)水平显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组氧化因子水平明显优于对照组,两组差异均有统计学意义(P<0.05)。治疗后,两组亲环素A(CyPA)、血小板活化因子(PAF)、MCP-1水平均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组促炎因子水平明显低于对照组,两组差异均具有统计学意义(P<0.05)。结论 丹红注射液联合脑苷肌肽注射液治疗急性脑梗死具有较好的临床疗效,能改善患者神经功能,提升患者日常生活能力、生存质量,调节体内氧化应激水平和炎症反应,减轻脑损伤,具有一定的临床推广使用价值。
[Key word]
[Abstract]
Objective To investigate the effects of Danhong Injection combined with Cattle Encephalon Glycoside and Ignotin Injection in treatment of acute cerebral infarction. Methods Patients (86 cases) with acute cerebral infarction in Shangluo Central Hospital from March 2016 to March 2018 were enrolled in this study. According to the difference treatment plan, patients were randomly divided into the control group (45 cases) and the treatment group (41 cases). Patients in the control group were iv administered with Cattle Encephalon Glycoside and Ignotin Injection, 20 mL added into normal saline 250 mL, once daily. Patients in the treatment group were iv administered with Danhong Injection on the basis of the control group, 20 mL added into normal saline 250 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and NIHSS scores, ADL scores, SS-QOL scores, oxidizing factor, and proinflammatory factor in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 95.12%, respectively, and there was difference between two groups (P<0.05). After treatment, NIHSS scores and ADL scores in two groups were significantly decreased, but SS-QOL scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the scores in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of MDA in two groups were significantly decreased, but the levels of SOD in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the oxidizing factor leveles in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of CyPA, PFA, and MCP-1 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the proinflammatory factor levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Danhong Injection combined with Cattle Encephalon Glycoside and Ignotin Injection has clinical curative effect in treatment of acute cerebral infarction, can improve neurological function, daily living ability, and quality of life of patients, regulate oxidative stress and inflammatory reaction, and alleviate brain injury, which has a certain clinical application value.
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[基金项目]
陕西省卫生厅青年科研基金资助项目(2012E9)