质子泵抑制剂（PPIs）是H⁺K⁺-ATP酶抑制剂，是当前应用最多的一类酸抑制药物，PPIs作用于胃黏膜上的质子泵，抑制H⁺的分泌，直接抑制胃酸产生。随着PPIs的应用越来越多，各种不良反应的报道也越来越多，且PPIs在老年人中的应用中存在疗程过长和适应症不适宜的问题。最新研究发现PPIs在老年患者中的使用可能会增加阿尔茨海默病的发生，综述了PPIs引起阿尔茨海默病发生的机制。

Proton pump inhibitors (PPIs) are H⁺K⁺-ATP inhibitors. They are currently the most populor acid-inhibitory drugs. They directly act on the proton pump of gastric mucosa by inhibiting the secretion of H⁺ and inhibiting the production of gastric acid. With the growth of application of PPIs, a variety of adverse reactions occurs. At present, the main problems of PPIs are its overuse and the errors in the therapeutic indication, especially in the elderly people. The latest literature demonstrated that long-term use of PPIs can increase the adverse effects of Alzheimer's disease. Research progress on mechanism of PPIs causing Alzheimer's disease are reviewed in this paper.