帕金森病是一种常见的神经变性疾病，特征性病理改变主要是黑质多巴胺能神经元丢失和路易小体的形成。路易小体中主要成分是纤维化的α-突触核蛋白，研究表明多巴胺能神经元中异常的蛋白质沉积可能与溶酶体自噬途径的失调有关。自噬调节剂的治疗潜力已在帕金森病动物模型中得到证实。海藻糖是一种天然双糖，被认为是治疗神经退行性疾病的新候选药物。它具有类似伴侣活性，防止蛋白质错误折叠或聚集，并有助于通过促进自噬去除积聚的蛋白质。总结异常自噬在帕金森病疾病发展过程中的潜在机制，讨论使用海藻糖对抗帕金森病的促进自噬、蛋白质稳定和抗神经炎症作用。

Objective Parkinson's disease is a common neurodegenerative disease. The characteristic pathological changes are mainly the loss of dopaminergic neurons in substantia nigra and the formation of Lewis bodies. The main component of Lewis bodies is fibrotic alpha synuclein. There is evidence that abnormal protein deposition in dopaminergic neurons may be related to the imbalance of lysosomal autophagy pathway. The therapeutic potential of autophagy regulators has been confirmed in animal models of Parkinson's disease. Trehalose is a natural disaccharide and is considered as a new candidate for the treatment of neurodegenerative diseases. It has chaperone-like activity, prevents protein from misfolding or aggregating, and helps remove accumulated proteins by promoting autophagy. The potential mechanism of abnormal autophagy in the development of Parkinson's disease is summarized. The role of trehalose in promoting autophagy, protein stability, and anti-neuroinflammation in the treatment of Parkinson's disease are also discussed in this paper.

北京协和医学院“中央高校基本科研业务费”资助项目（3332018181）