目的 对2016—2018年南阳市第一人民医院住院患者特殊使用级抗菌药物的使用情况进行分析，为规范科室合理使用提供管理思路。方法 对南阳市第一人民医院特殊使用级抗菌药物的使用率、销售金额、用药频度（DDDs）、使用强度（AUD）和科室分布等指标进行回顾性分析。结果 2016—2018年，特殊使用级抗菌药物的平均使用率为2.73%，美罗培南的销售金额始终处于首位。DDDs和AUD排名前3位的均为美罗培南、替考拉宁、盐酸头孢吡肟，呼吸内科、儿科和呼吸重症监护科的使用数量较多。结论 南阳市第一人民医院特殊使用级抗菌药物的使用频度过高，临床药师应积极参与进行针对性的管理。

Objective To study the utilization of special class antimicrobial drugs in Nanyang First People's Hospital from 2016 to 2018, and to provide management ideas for standardizing rational use in the department. Methods The utilization of special class antimicrobial drugs in Nanyang First People's Hospital was analyzed statistically in respect of the usage ratio, consumption sum, amount ratio, defined daily doses (DDDs), antibiotics use density (AUD), and department distribution. Results The average usage ratio of special class antimicrobial drugs in inpatient was 2.73% from 2016 to 2018. Consumption sum of meiluopeinan was always ranked the first. The top three DDDs and AUD of the special class antimicrobial drugs were meiluopeinan, teicoplanin, and cefepime dihydrochloride. Department of Respiratory Medicine, Paediatrics, and RICU had more use of special class antimicrobial drugs. Conclusion The use frequency of special class antimicrobial drugs in Nanyang First People's Hospital is higher, therefore clinical pharmacists should actively participate in targeted management.