目的 分析2016—2018年中国中医科学院广安门医院南区特殊使用级抗菌药物的使用情况。方法 调取中国中医科学院广安门医院南区2016—2018年特殊使用级抗菌药物的使用相关信息，对销售金额、用药频度（DDDs)、使用强度（AUD）和科室分布进行统计分析。结果 特殊使用级抗菌药物的销售金额下降但占比波动下降；抗耐甲氧西林金黄色葡萄球菌（MRSA）类特殊使用级抗菌药物的销售金额连续3年增长。碳氢酶烯类和抗真菌药的销售金额连续3年下降；抗MASA类药物DDDs增加，碳氢酶烯类药物DDDs下降，尤其是美罗培南。特殊使用级抗菌药物的AUD呈下降趋势，2016、2017年基本持平；特殊使用级抗菌药物的使用主要分布在重症监护室、肿瘤科、呼吸科、肾病科。结论 中国中医科学院广安门医院南区特殊使用级抗菌药物的AUD呈下降趋势，但同时存在很多问题，需要采取措施弥补不足，促进特殊使用级抗菌药物合理使用。

Objective To analyze the utilization of special class antimicrobial drugs in South Campus of Guang'anmen Hospital, China Academy of Chinese Medical Sciences from 2016 to 2018. Methods The use relevant information of special class antimicrobial drugs in South Campus of Guang'anmen Hospital, China Academy of Chinese Medical Sciences from 2016 to 2018 were selected, and consumption sum, defined daily doses (DDDs), antibiotics use density (AUD), and department distribution were analyzed. Results Consumption sum of special class antimicrobial drugs decreased, but the proportion fluctuated and on a declining curve. Consumption sum of anti-MASA special class antimicrobial drugs increased significantly for three years. Consumption sum of carbapenems and antifungals decreased for 3 consecutive years. DDDs of anti-MASA drugs increased, while DDDs of carbapenems decreased, especially meropenem. AUD of special class antimicrobial drugs had the trend of decrease, and AUD in 2016 and 2017 were basically equal. Special class antimicrobial drugs were mainly distributed in Intensive Care Unit, Department of Oncology, Department of Respiratory, and Department of Nephrology. Conclusion AUD in South Campus of Guang'anmen Hospital, China Academy of Chinese Medical Sciences has the trend of decrease, but there are still many problems. It is necessary to have more effort to promote rational use of special class antimicrobial drugs.