目的 探讨九味熄风颗粒联合可乐定透皮贴片治疗小儿抽动症的临床疗效。方法 选取2017年3月—2018年3月在濮阳市妇幼保健院治疗抽动症患儿82例，根据入院顺序分为对照组（41例）和治疗组（41例）。对照组给予可乐定透皮贴片，体质量≤40 kg者1.0 mg/次，1次/周；40 kg<体质量≤60 kg者1.5 mg/次，体质量＞60 kg者2.0 mg/次，1次/周。治疗组在对照组基础上口服九味熄风颗粒，4～6岁，1袋/次，2次/d；7～9岁，1.5袋/次，2次/d；10～14岁，2袋/次，2次/d。两组均治疗6周。观察两组患者临床疗效，同时比较治疗前后两组患者症状积分、血清谷氨酸（GLU)、门冬氨酸（ASP）、γ-氨基丁酸（GABA）水平及神经递质水平。结果 治疗后，对照组和治疗组临床有效率分别为80.49%和97.56%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者眨眼次数、眨眼频率、眨眼强度积分和YGTSS评分均显著降低（P<0.05），且治疗组患者上述积分明显低于对照组患者（P<0.05）。治疗后，两组患者血清GLU、ASP水平均显著降低（P<0.05），GABA水平显著升高（P<0.05），且治疗组患者GLU、Asp、GABA水平明显好于对照组患者（P<0.05）。治疗后，两组患者血清多巴胺（DA）、5-羟色胺（5-HT）与去甲肾上腺素（NE）水平显著均降低（P<0.05），且治疗组患者DA、5-HT、NE水平明显低于对照组患者（P<0.05）。结论 九味熄风颗粒联合可乐定透皮贴片治疗小儿抽动症可有效改善患儿临床症状，降低机体神经递质水平，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Jiuwei Xifeng Granules combined with Clonidine Transdermal Patches in treatment of tourette syndrome in children. Methods Children (82 cases) with tourette syndrome in Puyang Maternity and Child Care Centers from March 2017 to March 2018 were divided into control (34 cases) and treatment (34 cases) groups based on the admission order. Children in the control group were administered with Clonidine Transdermal Patches, 1.0 mg/time for the weight ≤ 40 kg, 1.5 mg/time for 40 kg < the weight ≤ 60 kg, 2.0 mg/time for the weight > 60 kg, once a week. Children in the treatment group were po administered with Jiuwei Xifeng Granules on the basis of the control group, 1 bag/time for 4-6 years old children, 1.5 bag/time for 7-9 years old children, 2 bags/time for 10-14 years old children, twice daily. Children in two groups were treated for 6 weeks. After treatment, the clinical efficacy was evaluated, and the clinical symptom scores, serum GLU, Asp and GABA levels, and the levels of neurotransmitters in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 80.49% and 97.56% respectively, and there were differences between two groups (P<0.05). After treatment, the blinking times frequency and intensity scores, and YGTSS scores in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than that in the control group (P<0.05). After treatment, the serum GLU and ASP levels in two groups were significantly decreased (P<0.05), but GABA levels were significantly increased (P<0.05), and the GLU, Asp and GABA levels in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the serum DA, 5-HT and NE levels in two groups were significantly decreased (P<0.05), and the DA, 5-HT and NE levels in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Jiuwei Xifeng Granules combined with Clonidine Transdermal Patches in treatment of tourette syndrome in children can effectively improve the clinical symptoms, reduce the body's neurotransmitter levels, which has a certain clinical application value.