目的 探讨寒喘祖帕颗粒联合沙美特罗替卡松治疗咳嗽变异性哮喘的临床效果。方法 选取2015年8月—2018年8月重庆市巴南区人民医院收治的咳嗽变异性哮喘患者68例，随机分成对照组（34例）和治疗组（34例）。对照组吸入沙美特罗替卡松粉吸入剂，1吸/次，2次/d。治疗组在对照组基础上口服寒喘祖帕颗粒，12 g/次，2次/d。两组患者连续治疗8周。观察两组患者临床疗效，同时比较治疗前后两组患者咳嗽症状积分、肺功能参数、外周血嗜酸性粒细胞数（EOS#）值和莱切斯特咳嗽问卷（LCQ）评分。结果 治疗后，对照组和治疗组临床有效率分别为76.5%和94.1%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组咳嗽症状积分均显著降低（P<0.05），且治疗组患者咳嗽症状积分明显低于对照组患者（P<0.05）。治疗后，两组第1秒用力呼气容积占预计值百分比（FEV1% pred）、呼气峰值流量占预计值百分比（PEF% pred）值均显著升高（P<0.05），呼气峰值流量（PEF）昼夜变异率、外周血EOS#值均显著降低（P<0.05），且治疗组患者肺功能参数及外周血EOS#值明显好于对照组（P<0.05）。治疗后，两组患者LCQ中各维度评分及总分均显著升高（P<0.05），且治疗组患者LCQ评分明显高于对照组（P<0.05）。结论 寒喘祖帕颗粒联合沙美特罗替卡松治疗咳嗽变异性哮喘，可有效控制咳嗽症状，提高患者肺功能，缓解气道炎症，疗效显著，且安全性较高。

Objective To investigate the clinical effect of Hanchuan Zupa Granules combined with shameiteluo in treatment of cough variant asthma. Methods Patients (68 cases) with cough variant asthma in Banan People's Hospital of Chongqing from August 2015 to August 2018 were randomly divided into control (34 cases) and treatment (34 cases) groups. Patients in the control group were inhalation administered with Salmeterol Xinafoate and Fluticasone Propionate Powder for inhalation, 1 inhalation/time, twice daily. Patients in the treatment group were po administered with Hanchuan Zupa Granules on the basis of the control group, 12 g/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the cough symptom scores, pulmonary function parameters, EOS# value of peripheral blood and LCQ scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 76.5% and 94.1% respectively, and there were differences between two groups (P<0.05). After treatment, the cough symptom scores in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than that in the control group (P<0.05). After treatment, the FEV1%pred and PEF%pred value in two groups was significantly increased (P<0.05), but diurnal variation rate of PEF and EOS# value of peripheral blood was significantly decreased (P<0.05), and pulmonary function and EOS# value of peripheral blood in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the LCQ score and total score in two groups were significantly increased (P<0.05), and these scores in the treatment group were significantly higher than those in the control group (P<0.05). Conclusion Hanchuan Zupa Granules combined with shameiteluo in treatment of cough variant asthma can effectively control cough symptoms, improve lung function, reduce airway inflammation with significant curative effect and high safety.