目的 了解2016—2018年天津医科大学代谢病医院住院药房降压药的使用情况，为临床合理用药提供依据。方法 采用WHO推荐的限定日剂量（DDD）法对天津医科大学代谢病医院住院药房降压药的用药金额、用药频度（DDDs）、日均费用（DDC）和排序比（B/A）等进行统计分析。结果 2016—2018年降压药的销售情况总体比较平稳，占比逐年升高。血管紧张素Ⅱ受体拮抗剂类药物的销售金额及构成比连续3年居首位，钙拮抗剂次之，利尿剂最低。具体药物中硝苯地平控释片的销售金额和DDDs在2016、2017年均排第1位，但2018年降到了第4位，苯磺酸氨氯地平片从2016年的第13位上升到2018年的第1位，增长幅度比较大。DDC最高的是琥珀酸美托洛尔缓释片，最低的是氢氯噻嗪片，大部分药品的B/A值都在1.00左右。结论 2016—2018年天津医科大学代谢病医院高血压患者降压药物的选择与使用相对合理，用药情况符合指南要求。

Objective To investigate the use of anti-hypertensive drugs in Tianjin Medical University Metabolic Disease Hospital from 2016 to 2018, and to provide reference for reasonable use of drugs. Methods Consumption sum, frequency of drug use (DDDs), defined daily cost (DDC), and drug sequence ratio (B/A) of anti-hypertensive drugs in Tianjin Medical University Metabolic Disease Hospital were analyzed retrospectively by defined daily doses (DDD) recommended by WHO. Results From 2016 to 2018, the sales of antihypertensive drugs were steady with little fluctuation. The sales amount and composition ratio of ARB ranked the first for three consecutive years, followed by CCB and diuretics. Nifedipine Controlled-release Tablets were the first in 2016 and 2017, but dropped to the fourth in 2018, and Amlodipine Besylate Tablets soared from the 13th in 2016 to the first in 2018. DDC of Metoprolol Succinate Sustained-release Tablets was the highest, while DDC of Hydrochlorothiazide Tablets was the lowest. B/A values of most drugs were around 1.00. Conclusion The selection of anti-hypertensive drugs in Tianjin Medical University Metabolic Disease Hospital is basically reasonable, which meets the requirements of clinical guidelines.

天津医科大学朱宪彝纪念医院科研基金资助项目（2018ZXY03）