目的 探讨桂枝茯苓胶囊联合达那唑胶囊治疗子宫肌瘤的临床疗效。方法 选择2017年1月—2018年1月天津市泰达医院收治的159例子宫肌瘤患者作为研究对象，依据随机分组原则将患者分为对照组（79例）和治疗组（80例）。对照组患者口服达那唑胶囊，从月经周期第1天开始服用，400 mg/d，连续服用6个月经周期。治疗组在对照组的基础上口服桂枝茯苓胶囊，4粒/次，3次/d，经期停服。3个月经周期为1个疗程，两组患者连续治疗2个疗程。观察两组患者的临床疗效，比较两组治疗前后的子宫和肌瘤体积、性激素水平和不良反应发生情况。结果 治疗后，对照组和治疗组的总有效率分别为78.48%、91.25%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者的子宫和肌瘤体积均明显减小，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗后治疗组的子宫和肌瘤体积显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组黄体生成素（LH）、卵泡刺激素（FSH）、孕酮（P）和雌二醇（E₂）水平均明显降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗后治疗组的激素水平显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗期间，治疗组患者的不良反应发生率为7.5%，显著低于对照组的17.72%，两组比较差异具有统计学意义（P<0.05）。结论 桂枝茯苓胶囊联合达那唑胶囊治疗子宫肌瘤具有较好的临床疗效，可明显缩小子宫与肌瘤体积，降低患者性激素水平，不良反应发生率低，具有较好的临床推广应用价值。

Objective To investigate the clinical efficacy of Guizhi Fuling Capsules combined with Danazol Capsules in treatment of uterine fibroids. Methods Patients (159 cases) with uterine fibroids in Tianjin TEDA Hospital from January 2017 to January 2018 were divided into control (79 cases) and treatment (80 cases) groups according to the principle of random grouping. Patients in the control group were po administered with Danazol Capsules from the first day of the menstrual cycle, and 400 mg/d for six consecutive menstrual cycles. Patients in the treatment group were po administered Guizhi Fuling Capsules on the basis of control group, 4 grains/time, three times daily, and stopped taking it during the menstruation. A course of treatment had 3 menstrual cycles, and patients in two groups were treated for 2 courses. After treatment, the clinical efficacy was evaluated, and the uterine and uterine fibroid volume, hormone levels and adverse actions in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 78.48% and 91.25%, respectively, and there were differences between two groups (P < 0.05). After treatment, the uterine and uterine fibroid volumes in two groups were significantly decreased, and the difference was statistically significant in the same group (P< 0.05). And the uterine and uterine fibroid volumes in the treatment group were significantly lower than those in the control group after treatment, with significant difference between two groups (P< 0.05). After treatment, the levels of LH, FSH, P and E₂ in the two groups were significantly decreased, and the difference was statistically significant in the same group (P< 0.05). And the hormone levels in the treatment group were significantly lower than those in the control group after treatment, with significant difference between two groups (P< 0.05). During the treatment, the incidence of adverse reactions in the treatment group was 7.5%, which was significantly lower than 17.72% in the control group, there were differences between two groups (P < 0.05). Conclusion Guizhi Fuling Capsules combined with Danazol Capsules has a good clinical efficacy in treatment of uterine fibroids, can significantly reduce the uterine and uterine fibroid volume, and decrease sex hormones level, with low incidence of adverse reactions, which has a certain clinical application value.