目的 探讨地黄叶总苷胶囊联合阿魏酸钠片治疗慢性肾小球肾炎的临床疗效。方法 选取2017年6月—2018年6月在上海市松江区泗泾医院治疗的慢性肾小球肾炎患者94例，根据门诊号分为对照组（47例）和治疗组（47例）。对照组患者口服阿魏酸钠片，100 mg/次，3次/d；治疗组在对照组基础上口服地黄叶总苷胶囊，0.4 g/次，2次/d。两组患者均连续治疗4周。观察两组患者临床疗效，同时比较治疗前后两组患者中医证候评分、24 h尿蛋白定量（24 h UPR）、血尿素氮（BUN）、血肌酐（Scr）和尿红细胞（RBC）水平及血清学指标和T淋巴细胞亚群水平。结果 治疗后，对照组和治疗组临床有效率分别为80.85%和95.74%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者中医症候评分显著下降（P<0.05），且治疗组患者中医证候评分明显低于对照组（P<0.05）。治疗后，两组患者24 h UPR、Scr、BUN及尿RBC水平显著降低（P<0.05），且治疗组患者24 h UPR、Scr、BUN及尿RBC水平明显低于对照组（P<0.05）。治疗后，两组血清白细胞诱导素1（LKN-1）、纤溶酶原激活物抑制物-1（PAI-1）、组织金属蛋白酶原抑制剂-1（TIMP-1）、转化生长因子-β1（TGF-β1）水平显著降低（P<0.05），组织型–纤维蛋白溶解酶原激活剂（t-PA）和基质金属蛋白酶-9（MMP-9）显著升高（P<0.05），且治疗组上述血清学指标水平明显好于对照组（P<0.05）。治疗后，两组患者血清CD3⁺、CD4⁺、CD4⁺/CD8⁺水平均明显升高（P<0.05），CD8⁺水平显著降低（P<0.05），且治疗组上述指标水平明显好于对照组（P<0.05）。结论 地黄叶总苷胶囊联合阿魏酸钠片治疗慢性肾小球肾炎可有效改善患者临床症状和肾功能，促进机体免疫功能改善，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Dihuangye Total Glycoside Capsules combined with sodium ferulate in treatment of chronic glomerulonephritis. Methods Patients (94 cases) with chronic glomerulonephritis in Sijing Hospital of Shanghai Songjiang District from June 2017 to June 2018 were divided into control (47 cases) and treatment (47 cases) groups based on outpatient number. Patients in the control group were po administered with Sodium Ferulate Tablets, 100 mg/time, three times daily. Patients in the treatment group were po administered with Dihuangye Total Glycoside Capsules on the basis of the control group, 0.4 g/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the TCM syndrome scores, 24 h UPR, Scr, BUN and RBC levels, the serological indicators and the levels of T lymphocyte subsets in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 80.85% and 95.74%, respectively, and there were differences between two groups (P < 0.05). After treatment, the TCM syndrome scores in two groups were significantly decreased (P < 0.05), and these scores in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the 24 h UPR, Scr, BUN and RBC levels in two groups were significantly decreased (P <0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the serum TGF-β1, TIMP-1, LKN-1 and PAI-1 levels in two groups were significantly decreased (P < 0.05), but MMP-9 and t-PA levels were significantly increased (P < 0.05), and these serological indicators levels in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the serum CD3⁺, CD4⁺ and CD4⁺/CD8⁺ levels in two groups were significantly increased (P < 0.05), but CD8⁺ levels were significantly decreased (P < 0.05), and these indicators levels in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion Dihuangye Total Glycoside Capsules combined with sodium ferulate in treatment of chronic glomerulonephritis can effectively improve the clinical symptoms and renal function and promote the immune function, which has a certain clinical application value.