目的 探讨益肾生发丸联合复方甘草酸苷胶囊治疗斑秃的临床疗效。方法 选取2017年5月—2018年5月在监利县人民医院治疗的82例斑秃患者作为研究对象，根据门诊号的奇偶数将患者分为对照组（41例）和治疗组（41例）。对照组口服复方甘草酸苷胶囊，3粒/次，3次/d；治疗组在对照组基础上口服益肾生发丸，9 g/次，2次/d。两组均治疗3个月。观察两组患者的临床疗效，同时比较两组患者治疗前后血管内皮生长因子（VEGF）、Fas、FasL表达、血清学指标和T淋巴细胞亚群水平。结果 治疗后，对照组和治疗组的总有效率分别为80.49%、97.56%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组毛囊VEGF表达均明显降低，Fas、FasL表达均显著增高，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组VEGF表达明显低于对照组，而Fas、FasL表达显著高于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清转化生长因子-β1（TGF-β1）、肿瘤坏死因子-α（TNF-α）、白细胞介素-17（IL-17）、SP水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组血清学指标显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清CD3⁺、CD4⁺、CD4⁺/CD8⁺水平均显著增高，CD8⁺水平显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组T淋巴细胞亚群水平明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 益肾生发丸联合复方甘草酸苷胶囊治疗斑秃具有较好的临床疗效，可有效降低血管内皮细胞生长因子表达，降低机体炎症反应，提高机体免疫功能，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Yishen Shengfa Pills combined with Compound Glycyrrhizin Capsules in treatment of alopecia areata. Methods Patients (82 cases) with alopecia areata in Jianli County People's Hospital from May 2017 to May 2018 were divided into control group (41 cases) and treatment group (41 cases) according to the odd and even number of outpatient numbers. Patients in the control group were po administered with Compound Glycyrrhizin Capsules, 3 grains/time, three times daily. Patients in the treatment group were po administered with Yishen Shengfa Pills on the basis of the control group, 9 g/time, twice daily. Patients in two groups were treated for 3 month. After treatment, the clinical efficacy was evaluated, and the expressions of VEGF, Fas and FasL, serological indicators, and the levels of T lymphocyte subsets in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 80.49% and 97.56%, respectively, and there were differences between two groups (P < 0.05). After treatment, the expressions of VEGF in the hair follicle in two groups were significantly decreased, but the expression of Fas and FasL were increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the expression of VEGF in the hair follicle in the treatment group were significantly lower than those in the control group, but the Fas and FasL were higher than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the expressions of TGF-β1, TNF-α, IL-17, and SP in two groups were significantly decreased, and there were differences in the same group (P < 0.05). After treatment, serological indicators in the treatment group were significantly lower than those in the control group, and there were differences between two groups (P < 0.05). After treatment, CD3⁺, CD4⁺ and CD4⁺/CD8⁺ levels in two groups were significantly increased, but the CD8⁺ levels were decreased, and there were differences in the same group (P < 0.05). After treatment, the levels of T lymphocyte subsets in the treatment group were significantly better than those in the control group, and there were differences between two groups (P < 0.05). Conclusion Yishen Shengfa Pills combined with Compound Glycyrrhizin Capsules has a good clinical effect in treatment of alopecia areata, can effectively reduce the expression of vascular endothelial cell growth factor and inflammatory reaction, and improve the immune function, which has a certain clinical application value.